Professor Mike White said, “TNF is a very important molecule and our team has shone light on the way cells control excessive amounts of the TNF, which may be important for the progression of chronic inflammatory diseases”
Professor Dean Jackson said “Our immune systems are highly sophisticated and mechanisms of communication between different cells must be exquisitely controlled. In inflammatory diseases such as IBD this fine tuning is lost and the system runs out of control - like a snowball running down a hill. If we can develop better drugs to manipulate cell communication the outcome for patients should be improved.”
This research was funded by BBSRC, in collaboration with EU funded SysmedIBD consortium, which is pioneering a new approach to IBD called ‘systems medicine’ in which the best treatment options are predicted by looking at disease as a part of an integrated whole, combining all biochemical, physiological and environmental interactions.
Scientific Coordinator of SysmedIBD, Professor Werner Muller, from The University of Manchester said: “Though some years away, ‘systems medicine’ could save the NHS money, and protect patients from the trauma of trying medicines for months or even years which fail to impact on the distressing symptoms of IBD. This research by Dr Paszek is another step along the path of making this approach a reality”
The paper “Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states” is published in Nature Communications.
The research team is available for comment.
SysmedIBD of an international collaboration UK, Germany, the Netherlands, Israel and New Zealand are involved in the project. Visit http://ift.tt/29xQKPr
Research brings new understanding of chronic inflammatory disease
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