The Summit comes at the same time that Dr Adam Darwich has been appointed Certara Lecturer in Precision Dosing at the Manchester Pharmacy School. Certara has endowed this lectureship, which is part of the University’s precision medicine initiative. A leader in the field, Manchester is one of six initial regional centres of excellence for The Precision Medicine Catapult, the UK’s innovation centre for precision medicine.
Dr Darwich will co-chair the Summit, which also includes speakers from the United States, France, Germany, Switzerland and Australia. Discussions will range from the application of precision dosing for patients with conditions such as HIV infection and cancer, to heart failure and transplant recovery. In all of these cases, the dosing level of drugs can be optimised based on factors such as age, sex, weight and genetics – assuming the right environment exists to enable the use of the technique.
Professor of Systems Pharmacology, Amin Rostami, convened the conference. He said: “We have the mathematical techniques to ensure that patients receive the correct drug dose for their individual needs, and to minimise any interactions that could occur with other medications they may need to take. However, the current framework in which this science works is restrictive.
“While these rules are in place for good reason, they are beginning to look outdated and by gathering this global panel of experts we hope to be able to make concrete recommendations for change leveraging various new technologies.”
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If the drug fits: For the first time experts meet to address barriers to personalised drug dosing
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